Left Atrium Reservoir Function Modulation in Patients With Atrial Fibrillation: Digoxin Versus Beta Blocker

• Status: Recruiting
• Trial end date: 2023-12-01
• Target enrollment: 0
• Participant gender: All

Summary

ß blocker and digoxin effect on left atrium reservoir function are unknown. This is a randomized open label study to compare the effect of theses two molecules on left atrium function

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Monastir
• Treatments: Bisoprolol; Digoxin

Criteria

Inclusion Criteria:

• Any patient with atrial fibrillation naïve to ß-blocker and digoxin or patients followed for Atrial fibrillation and discontinued all treatment for more than a week.

• Frequency Control Strategy Decided

• Age over 18 years

• Stable hemodynamic state

• No contraindication to digoxin or ß-blocker

Exclusion Criteria:

• Required rhythm control strategy

• Contraindication to one of the two

• Heart rate <60 BPM

• Clearance rénale <30 ml/mn

• Pregnant or breastfeeding woman

• Persistence of a resting heart rate > 110

• Severe comorbidity with decreased life expectancy (advanced neoplasia, large stroke...)