Left Atrial Mechanical Function Improvement After Atrial Fibrillation Catheter Ablation

• Status: Completed
• Trial end date: 2016-02-01
• Target enrollment: 0
• Participant gender: All

Summary

The objective of the study was to estimate the efficacy of telmisartan and amlodipine combination on the restoration of left atrial mechanical function after atrial fibrillation catheter ablation.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Research Institute for Complex Problems of Cardiovascular Diseases, Russia
• Treatments: Amlodipine; Telmisartan; Telmisartan amlodipine combination

Criteria

Inclusion Criteria:

• Symptomatic (III-IV class by European Heart Rhythm Association scale) paroxysmal atrial fibrillation;

• Ineffective therapy by at least one of the class I or III antiarrhythmic drugs;

• Left atrial diameter 5 cm or less;

• Estimated catheter radiofrequency pulmonary vein antrum isolation;

• Signed informed consent.

Exclusion Criteria:

• Intolerance/allergy or contraindications to telmisartan, amlodipine, warfarin or enoxaparin;

• Left atrial thrombosis;

• Age greater than 75 years;

• Severe (e.g. decompensation of vital functions) or acute (e.g. pneumonia) somatic conditions;

• Malignant growth in the hematogenic dissemination stage.