Leflunomide Associated With Topical Corticosteroids for Bullous Pemphigoid

• Status: Unknown status
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Bullous pemphigoid (BP) is the most common blistering auto-immune disease of skin with an incidence estimated to 400 new cases per year. Topical corticosteroid therapy is considered the standard treatment for bullous pemphigoïd in 2002. Topical corticosteroid requires an initial large hospitalization during the acute phase and rehospitalization during relapse. The usefulness of immunosuppressive drugs have suggested by uncontrolled study.

In this way, leflunomide could be an alternative therapy, and to reduce relapse and/or resistance risks.

This study could prove the efficacity of leflunomide, associated with short time topical corticosteroids.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital, Limoges
• Treatments: Leflunomide

Criteria

Inclusion Criteria:

• Adult ≥ 65 years old

• Bullous pemphigoid :

• Newly diagnosed bullous pemphigoid : No treatment or topical corticosteroids therapy for less than one month

• BP diagnosed : Resistance of the BP to the treatment or recurrence 6 months at least after diagnosis

• Follow up monthly during one year accepted

• Written Inform Consent

Exclusion Criteria:

• None