Lateral Canthal Rhytides With Medium Depth Chemical Peel With or Without Pretreatment With Botulinum Toxin A

• Status: Completed
• Trial end date: 2013-05-01
• Target enrollment: 0
• Participant gender: All

Summary

This study is being done to find out if the use of botulinum toxin prior to a medium strength combination chemical peel (Jessner's peel followed by 35% Trichloroacetic acid peel) will improve the appearance of crow's feet wrinkles when compared to a chemical peel alone. Botulinum toxin type A is a purified substance, derived from a bacteria that block muscular nerve signals. Jessner's Peel, a combination of resorcinol (14g), salicylic acid (14g), and lactic acid (85%) in ethanol (95%), is a superficial chemical peel. These two products/procedures have been FDA approved to improve the appearance of facial wrinkles.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Loyola University
• Treatments: abobotulinumtoxinA; Botulinum Toxins; Botulinum Toxins, Type A; incobotulinumtoxinA; onabotulinumtoxinA

Criteria

Inclusion Criteria:

• Age 30 to 75 years old

• In good health

• Has static and dynamic lateral canthal wrinkles ("crow's feet")

• Has the willingness and the ability to understand and provide informed consent and communicate with the investigator

Exclusion Criteria:

• Pregnant or lactating

• Has received the following treatments:

• botulinum toxin injections in the past 6 months

• ablative laser procedure in the past 6 months

• radiofrequency device treatment in the past 6 months

• ultrasound device treatment in the past 6 months

• medium to deep chemical peel in the past 6 months

• temporary soft tissue augmentation material in the past year

• semi-permanent soft tissue augmentation material in the past 2 years

• permanent soft tissue augmentation material

• Is planning to receive within the next 3 months, any cosmetic procedure (such as any chemical peels, botulinum toxin injections, ablative or non-ablative laser procedures, filler injections, radiofrequency procedures, dermabrasion, ultrasound and face lifting procedures)

• Has an active infection on their face (excluding mild acne

• Has a history of neuromuscular disorders

• Has an allergy to albumin

• Has an allergy to Aquaphor AND petroleum jelly

• Has a history of bleeding disorders

• Is unable to understand the protocol or to give informed consent

• Has a mental illness