Latanoprost Versus Tafluprost: 24-hour Intraocular Pressure (IOP)
Status:
Completed
Trial end date:
2012-04-01
Target enrollment:
Participant gender:
Summary
- Main objective is to compare the ability of Latanoprost 0.005% preservative-added
ophthalmic solution versus Tafluprost 0.0015% preservative-free ophthalmic solution,
both given once a day at the evening, in reducing 24-hour intraocular pressure (IOP) in
patients with primary open angle glaucoma (POAG) and/or ocular hypertension (OHT) at
first diagnosis. First efficacy variable will be the difference between mean nocturnal
IOP values after three months of treatment: nocturnal IOP is defined as the mean value
between 2AM and 6AM measurements.
- Secondary objectives will be the comparison between Latanoprost 0.005% and Tafluprost
0.0015% ophthalmic solution about:
- Mean 24-hour IOP values after three months of treatment
- IOP values at these time-points: 10AM (± 1 hour), 2PM (± 1 hour), 6PM (± 1 hour),
10PM (± 1 hour), 2AM (± 1 hour) and 6AM (± 1 hour) after three months of treatment
Phase:
Phase 4
Details
Lead Sponsor:
Azienda Ospedaliera Spedali Civili di Brescia Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia