The current study aimed to investigate the effect of the combined Nd-Er: YAG laser on the
surgical treatment of peri-implantitis by evaluating clinical markers and biomarkers of bone
loss (RANKL/OPG). Twenty (20) patients having at least 1 implant diagnosed with
peri-implantitis were randomly assigned to two groups for surgical treatment. In the test
group (n=10), Er: YAG laser was used for granulation tissue removal and implant surface
decontamination, while Nd: YAG laser was employed for deep tissue decontamination and
biomodulation. In the control group (n=10), an access flap was applied, and mechanical
instrumentation of the implant surface was performed by using titanium curettes. The
following clinical parameters were evaluated at baseline and six months after treatment:
Full-mouth Plaque Score (FMPS), Probing Pocket Depth (PPD), Probing Attachment Levels (PAL),
recession (REC), and Bleeding on probing (BoP). Peri-implant crevicular fluid (PICF) was
collected at baseline and six months for the evaluation of soluble RANKL and OPG utilizing
enzyme-linked immunosorbent assay (ELISA).