Large Doses of Methylprednisolone Combined With Gabapentin in Total Knee Arthroplasty
Status:
Completed
Trial end date:
2020-05-01
Target enrollment:
Participant gender:
Summary
The aim of the study was to assess whether administration of gabapentin and
methylprednisolone as "pre-emptive analgesia" in a group of patients above 65 years of age
would be effective in complex pain management therapy following total knee arthroplasty
(TKA). For the study investigators will qualify one hundred seventy, above 65 years old
patients. The participants will be double-blind randomized into two groups: the study and
controls The study group will receive as "pre-emptive" analgesia a single dose of 300 mg oral
gabapentin and 125 mg intravenous methylprednisolone, while the others placebo.
Perioperatively, all the patients will receive opioid and nonopioid analgesic agents
calculated for 1 kg of body weight. Investigators will measure the levels of inflammatory
markers (leukocytosis, C-reactive protein - CRP), pain intensity level at rest (numerical
rating scale - NRS), the life parameters and all complications.