Lapatinib in Combination With Radiation Therapy in Patients With Brain Metastases From HER2-Positive Breast Cancer
Status:
Completed
Trial end date:
2012-06-01
Target enrollment:
Participant gender:
Summary
The purpose of this research study is to determine the safety of combining lapatinib plus
radiation in patients with breast cancer that has spread to the brain. Depending upon the
participants cancer, they may also have stereotactic radiosurgery (SRS). Lapatinib s a
compound that may stop cancer cells from growing abnormally. It is thought that lapatinib
might also make cancer cells more sensitive to radiation. This drug has been used in other
research studies in women with breast cancer, and information from those other research
studies suggests that lapatinib may help to shrink or stabilize breast tumors both inside the
brain and outside the brain.
Phase:
Phase 1
Details
Lead Sponsor:
Nancy Lin, MD
Collaborators:
Breast Cancer Research Foundation Brigham and Women's Hospital GlaxoSmithKline