Lapatinib and Paclitaxel in Treating Patients With Advanced Solid Tumors
Status:
Completed
Trial end date:
2013-12-01
Target enrollment:
Participant gender:
Summary
RATIONALE: Drugs used in chemotherapy, such as paclitaxel, work in different ways to stop the
growth of tumor cells, either by killing the cells or by stopping them from dividing.
Lapatinib may help paclitaxel work better by making tumor cells more sensitive to the drug.
Lapatinib may also stop the growth of tumor cells by blocking some of the enzymes needed for
cell growth. Giving lapatinib together with paclitaxel may kill more tumor cells.
PURPOSE: This phase I trial is studying the side effects and best dose of lapatinib when
given together with paclitaxel in treating patients with advanced solid tumors.