Overview

Lapatinib Resistance in Patients With Breast Cancer

Status:
Withdrawn
Trial end date:
1969-12-31
Target enrollment:
0
Participant gender:
All
Summary
RATIONALE: Studying samples of tumor tissue and blood from patients with cancer in the laboratory may help doctors learn more about cancer and the development of drug resistance in patients. PURPOSE: This research study is looking at lapatinib resistance in patients with breast cancer.
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Case Comprehensive Cancer Center
Collaborator:
National Cancer Institute (NCI)
Treatments:
Lapatinib
Criteria
DISEASE CHARACTERISTICS:

- Pathologically confirmed invasive breast cancer

- ErbB2-positive disease

- Has received or is currently receiving lapatinib ditosylate

- Documented clinical benefit while receiving lapatinib ditosylate (e.g., stable
disease of ≥ 12 weeks duration OR a radiographic response)

- Must have tumor tissue samples available for research studies

- Hormone receptor status not specified

PATIENT CHARACTERISTICS:

- Menopausal status not specified

- Not pregnant*

- Coagulation profile normal*

- Platelet count > 100,000/mm³* NOTE: *For patients requiring a post-treatment biopsy

PRIOR CONCURRENT THERAPY:

- See Disease Characteristics

- Concurrent chemotherapy or trastuzumab (Herceptin®) allowed

- No concurrent anticoagulants, including warfarin or low-molecular weight heparin*

- No concurrent antiplatelet therapy, including aspirin, clopidogrel, or other
antiplatelet agents* NOTE: *For patients requiring a post-treatment biopsy