Lapatinib Ditosylate, Trastuzumab, Paclitaxel, and Surgery in Treating Patients With Breast Cancer
Status:
Completed
Trial end date:
2016-08-15
Target enrollment:
Participant gender:
Summary
This phase II trial studies how well giving lapatinib ditosylate together with trastuzumab,
paclitaxel, and surgery works in treating patients with breast cancer. Lapatinib ditosylate
may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Monoclonal antibodies, such as trastuzumab, can block tumor growth in different ways. Some
block the ability of tumor to grow and spread. Others find tumor cells and help kill them or
carry cancer-killing substances to them. Drugs used in chemotherapy, such as paclitaxel, work
in different ways to stop the growth of tumor cells, either by killing the cells or by
stopping them from dividing.