Postoperative atrial fibrillation is a common complication after cardiac surgery and is
associated with an elevation of morbidity and mortality. The recommended treatment includes
heart rate control with a beta blocker. Landiolol is a new-generation beta-blocker with
favourable pharmacologic properties making an interesting drug to treat postoperative atrial
fibrillation. However, Landiolol micro and macrocirculatory effects in the setting of atrial
fibrillation are yet to describe. The aim of this study is to describe microcirculatory
effects of incremental doses of landiolol in postoperative atrial fibrillation compared to a
placebo. Our hypothesis is Landiolol will improve microcirculation disorders.