Lactated Ringer's Versus 5% Human Albumin: Cardiac Surgical Patients
Status:
Terminated
Trial end date:
2017-10-09
Target enrollment:
Participant gender:
Summary
The purpose of this study is to show which of two different types of fluid is best for
cardiac surgical patients. During and after the subject's heart surgery, the subject will be
given either Lactated Ringer's or 5% human albumin to replace lost blood and body fluids and
to regulate blood pressure.
Albumin (human) 5% is a sterile, liquid preparation of albumin derived from large pools of
human plasma. All units of human plasma used in the manufacture of Albumin (human) 5% are
provided by FDA approved blood establishments only.
Lactated Ringer's is a sterile, nonpyrogenic solution containing isotonic concentrations of
electrolytes in water for injection. It is FDA approved for administration by intravenous
infusion for parental replacement of extracellular losses of fluid and electrolytes.
The hypothesis of this study is that the individual total fluid volume and alveolar-arterial
gradient will be less with 5% human albumin compared to Lactated Ringer's in the
perioperative cardiac surgical patient.