Tight glucose control in intensive care has become a major concern, allowing a reduction in
morbidity and mortality. However, its use is limited by the percentage of hypoglycemia which
can have severe consequences on the brain. The bispectral index (BIS) is derived from the EEG
and measures of brain electrical activity noninvasively. It has already been shown that its
value changes according to hypoglycemia and its correction. Furthermore, if the hormonal
response to hypoglycemia is well known in healthy and diabetic subjects, it is not the case
in ICU patient. The usual treatment of hypoglycemia is based on parenteral infusion of
glucose. Btu this can lead to a hyperglycemic rebound that can be deleterious. Lactate is a
substrate for gluconeogenesis and an energy substrate during critical situations. It has been
shown to improve neurological tests during hypoglycaemia and had cerebral protective
properties after a severe head injury. The hypothesis of this study is that sodium lactate is
superior than the 30% glucose to correct hypoglycemia in the ICU in terms of glycemic
variation, brain function and hormonal response.