Overview

LPD+α-ketoacids on Autophagy and Improving Muscle Wasting in CKD

Status:
Unknown status

Trial end date:
2019-05-01

Target enrollment:
0

Participant gender:
All

Summary

To investigate the effects of different dietary regimens on muscle wasting, insulin/IGF-1 resistance. Further, to explore whether LPD+KA decrease the activation of autophagy associate with insulin/IGF-1 pathway.

Phase:

Phase 4

Accepts Healthy Volunteers?

Details

Lead Sponsor:

YUAN Wei-jie

Criteria

Inclusion Criteria:

- patients agree to participate in this study; age≥18 years and<70years; renal function
measured with creatinine clearance<60 and >15 ml/min (three monthly consecutive
measurements)；at least 6 months of follow up at our clinic before recruitment and
haven't received any diet intervention.

Exclusion Criteria:

- pregnant patients; diabetes; heart or liver failure; a recent myocardial infarction
(in the last 12 months); long term immobilization; chronic respiratory failure;
cancer; any pharmacological treatment that could modify muscle structure or function
such as glucocorticoids or insulin；Contraindications of Ketosteril, such as
hypersensitivity to the active substances or to any of the excipients, hypercalcaemia,
disturbed amino acid metabolism to the study protocol.