LOD vs Gn in Anovulatory PCOs Resistant to First Line Agents
Status:
Not yet recruiting
Trial end date:
2022-08-01
Target enrollment:
Participant gender:
Summary
PCOS is a complex disease that is diagnosed by the presence of two of the following three:
oligo/anovulation, clinical and/or biochemical hyperandrogenism, or polycystic ovaries by
ultrasound . PCOS affects 4% to 21% of females in reproductive age . Although subfertility is
abundant in women with PCOS, a majority of these women will achieve pregnancy naturally or by
treatment.
Different treatment modalities are present for ovulation induction. Life style modifications
including weight loss are encouraged for those who are overweight or obese. Pharmacological
induction of ovulation represent the first line therapy for induction of ovulation. Options
include aromatase inhibitors (Letrozole), Clomiphene Citrate (CC) or Metformin, alone or in
combinations.
For second line treatment either Gonadotropins (Gn) or laparoscopic ovarian surgery (LOS) are
the recommended options .
the objective of the trial is to study the effectiveness and safetey of surgical induction of
ovulation strategy and compare it to medical induction strategy with Gonadotropins