Overview

LDL Receptor Under Ezetimibe and Simvastatin

Status:
Completed
Trial end date:
2004-07-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to investigate the effects of the two lipid -lowering drugs, ezetimibe and simvastatin, on lipid metabolism in humans. In specific, the study will investigate in blood cells whether the enzyme that controls cholesterol synthesis, HMG-CoA reductase, and the receptor that takes up cholesterol from the blood, the LDL receptor, are changed during treatment with the aforementioned drugs.
Phase:
Phase 4
Details
Lead Sponsor:
University of Cologne
Collaborator:
Merck Sharp & Dohme Corp.
Treatments:
Ezetimibe
Simvastatin