Overview LCH-IV, International Collaborative Treatment Protocol for Children and Adolescents With Langerhans Cell Histiocytosis Status: Recruiting Trial end date: 2023-07-01 Target enrollment: Participant gender: Summary The LCH-IV is an international, multicenter, prospective clinical study for pediatric Langerhans Cell Histiocytosis LCH (age < 18 years). Phase: Phase 2/Phase 3 Details Lead Sponsor: North American Consortium for HistiocytosisCollaborator: Histiocyte SocietyTreatments: 6-MercaptopurineAntibodiesCladribineCytarabinegamma-GlobulinsImmunoglobulinsImmunoglobulins, IntravenousIndomethacinMercaptopurineMethotrexatePrednisoneRho(D) Immune GlobulinVinblastine