L-citrulline and Metformin in Becker's Muscular Dystrophy

• Status: Completed
• Trial end date: 2015-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of the study is to compare the effects of L-citrulline and metformin and their combination therapy on muscle function and force in patients with Becker muscular dystrophy (BMD).

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital, Basel, Switzerland
• Treatments: Metformin

Criteria

Inclusion Criteria:

• 18 years or older

• Molecular or immunohistochemical diagnosis of BMD

• ambulant at the time point of screening

Exclusion Criteria:

• Participation in another therapeutic BMD study within the last 3 months

• Use of L-Arginine, L-Citrulline or Metformin within the last 3 months

• Other chronic disease or relevant limitation of renal, liver, heart function according to discretion of investigator

• known hypersensitivity to L-citrulline or metformin