Overview

L-NMMA Dose-response Study in Healthy Subjects

Status:
Completed
Trial end date:
2010-06-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to investigate the effect of different levels of nitric oxide inhibition on blood pressure and arterial stiffness in healthy subjects. L-NMMA, an inhibitor of the nitric oxide synthase, is administered as bolus injection followed by continuous infusion, and is expected to raise blood pressure and arterial stiffness according to L-NMMA dose.
Phase:
Phase 1
Details
Lead Sponsor:
Regional Hospital Holstebro
Treatments:
omega-N-Methylarginine