L-Cit and Endothelial Function

• Status: Not yet recruiting
• Trial end date: 2024-02-28
• Target enrollment: 0
• Participant gender: All

Summary

The effect of L-Citrulline is well studied in relation to muscle strength, exhaustion, exercise performance, and endothelial function in health and disease. This study will extend current body of knowledge and will investigate the effect of L-Citrulline on brain vascular function.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Oklahoma

Criteria

Inclusion Criteria:

• Age 21-45 and ≥55-90 years of age

• Adequate hearing and visual acuity to participate in the examinations

• Ability to read and write in English

• Competence to provide informed consent

Exclusion Criteria:

• Active CNS disease including multiple sclerosis, uncontrolled seizures, active brain cancer

• Cerebrovascular accident other than TIA within 60 days prior to Visit 0

• Major psychiatric disease, including major depression not currently controlled on medications, alcohol or drug abuse

• Treatment with other Citrulline enhancers (L-Arginine, L-Citrulline Malate) within 4 weeks prior to Visit 0

• Any other medical condition which, in the opinion of investigator, would render the patient inappropriate or too unstable to complete the study protocol