Kidney Response to Sepsis Affects Angiogenic Balance and Likelihood of CCI and PICS
Status:
Recruiting
Trial end date:
0000-00-00
Target enrollment:
Participant gender:
Summary
This study investigates the mechanism by which kidney dysfunction perpetuates inflammation,
immunosuppression, and catabolism (PICS) in chronic critical illness. The investigators will
test the hypothesis that persistent kidney dysfunction in sepsis associated by chronic
critical illness contributes to decreased survival through the development of PICS. In
chronic critical illness, the persistence of the inflammatory state may lead to capillary
rarefication in the kidney causing accelerated chronic kidney disease. Progression of
chronic kidney disease during chronic critical illness can drive PICS. Indeed, many of the
features of chronic critical illness are consistent with the protein-energy malnutrition and
muscle wasting associated with chronic kidney disease. Thus, the kidney can play a
contributory role in chronic critical illness and PICS.
Phase:
Phase 4
Details
Lead Sponsor:
University of Florida
Collaborators:
National Institute of General Medical Sciences (NIGMS) National Institutes of Health (NIH)