Ketamine in Colorectal Surgery

• Status: Withdrawn
• Trial end date: 2018-08-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will evaluate the effectiveness of ketamine infusions in the management of acute pain following open or laparoscopic colorectal surgery cases. Half of patients will receive the institutional standard of care and a placebo infusion (no active medication). The other half of patients will receive the institutional standard of care and a ketamine infusion. All subjects and staff will be blinded as to whether they are receiving placebo or ketamine.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Medical College of Wisconsin
• Treatments: Acetaminophen; Alvimopan; Analgesics, Opioid; Ketamine; Morphine; Narcotics; Pharmaceutical Solutions

Criteria

Inclusion Criteria:

1. Age greater than 18 years

2. Surgical intervention required for the management of colonic disease

3. Admission to either the acute care surgery or colorectal surgery service with an anticipated inpatient hospital stay of 72 hours.

Exclusion Criteria:

1. History of adverse reaction to ketamine

2. Chronic opioid therapy for >3 weeks of >30mg oral morphine equivalents per day

3. Known substance abuse with prescription opioids or heroin

4. Anticipated post-operative intubation (>6hr duration)

5. History of psychosis

6. Active delirium

7. Glaucoma

8. Active acute coronary syndrome

9. Severe, poorly controlled hypertension (systolic blood pressure > 180)

10. Concurrent use of monoamine oxidase inhibitors (MAOIs)

11. Pregnancy

12. Prisoners