This study is designed to compare the effectiveness of two medications, Ketamine and
Midazolam, for rapidly relieving suicidal thoughts in people suffering from bipolar
depression.
The first drug, ketamine, is an experimental antidepressant that early studies have shown may
quickly reduce suicidal thoughts, but we are not sure how well it may work. Midazolam, the
comparison drug, is not thought to reduce depression or suicidal thoughts.