Ketamine-fentanyl VS Fentanyl for Analgosedation in SICU
Status:
Unknown status
Trial end date:
2021-06-01
Target enrollment:
Participant gender:
Summary
This is a randomized, double-blinded study to evaluate the analgosedative effect of ketamine
in a surgical intensive care unit. The patients who will receive continuous fentanyl infusion
for either pain control or sedation will be recruited in this trial. Fentanyl will be
titrated with initial loading doses of 20 mcg until the numeral rating scale(NRS) less than 4
or critical care pain observation tool (CPOT) less than 3 or Richmond agitation sedation
score (RASS) -2-0. Then the patients will be randomised in to receive saline infusion in
control group (Group C) or ketamine infusion in ketamine group (Group K). Ketamine will be
administered with an initial bolus of 0.3 mg/kg followed by a perfusion of1.5 mcg/kg/min
during the first 48 h. The dose of fentanyl will be protocolized adjusted according to NRS or
CPOT or RASS.