Ketamine as a Rapidly-Acting Antidepressant in Depressed Emergency Department Patients
Status:
Completed
Trial end date:
2017-03-01
Target enrollment:
Participant gender:
Summary
Investigators will conduct a trial to evaluate the use of Ketamine as an alternate treatment
for people with Major Depressive Disorder. This study plans to explore the potential that
Ketamine's rapid antidepressant action holds for improving outcomes in patients presenting to
the Emergency Department with severe depression. Since this is a controlled trial we will use
an IV of Ketamine or and equivalent volume of Diphenhydramine. Subjects will be randomly
assigned to receive Ketamine or Benadryl. Investigators will then compare measures of mood
pre- and post-infusion in the Emergency Department. To supplement self-reported measures of
depressive symptoms(e.g. mood), investigators will obtain objective measures of the
biological aspects of Major Depressive Disorder.
Phase:
Phase 2
Details
Lead Sponsor:
New York University School of Medicine NYU Langone Health