Ketamine and Neurofeedback-Training: Effects on Neuroplasticity in Cocaine Addiction
Status:
Recruiting
Trial end date:
2026-03-01
Target enrollment:
Participant gender:
Summary
The goal of this clinical trial is to learn about the effects of the combination of ketamine
and realtime functional magnetic resonance imaging (fMRI) neurofeedback training in
individuals with cocaine use disorder. The main questions the investigators aim to answer
are:
- Can the investigators observe a positive, significant effect on percentage of cocaine
use days of both interventions combined as well as stand alone interventions?
- Is there a significant transfer effect of the neurofeedback training?
- Is there a significant, ketamine-dependent change in glutamate levels in the nucleus
accumbens?
Participants will be given ketamine and a realtime fMRI neurofeedback training. Both
interventions are placebo-controlled. The investigators will compare the four intervention
groups to investigate the effects of the stand-alone effects of the intervention and the
combination of it.
Phase:
Phase 2
Details
Lead Sponsor:
Dr. med. Marcus Herdener
Collaborators:
University of Campania "Luigi Vanvitelli" University of Vienna University of Zurich