Ketamine and Glutamate After Brain Injury : a Microdialysis Study

• Status: Unknown status
• Trial end date: 2017-05-01
• Target enrollment: 0
• Participant gender: All

Summary

The objective of the study is to compare the effects of 48 hours ketamine infusion versus sufentanil infusion on brain glutamate concentrations measured with microdialysis after traumatic brain injury.

We hypothesize that ketamine infusion will decrease high glutamate values faster than sufentanil.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Pierre-Julien CUNGI
• Treatments: Ketamine; Sufentanil

Criteria

Inclusion Criteria:

• > 18 years old

• Glasgow Coma Scale (GCS) < 9

• > 3 days of sedation expected at the arrival

Exclusion Criteria:

• pregnancy

• < 18 years old

• estimated survival < 48 hours post-trauma

• expected sedation < 3 days

• coagulation impairment (platelets<100.000/mm3 and prothrombin time (TP) <60%)

• Cardiac arrest before ICU admission

• Admission > 12 hours after trauma

• Multimodal monitoring implanted > 24 hours post trauma

• Participation to the study refused by the next of kind

• No next of kind