Ketamine & Crisis Response Plan for Suicidal Ideation in the ED
Status:
Not yet recruiting
Trial end date:
2025-12-01
Target enrollment:
Participant gender:
Summary
The goal of this randomized pilot trial is to assess the feasibility of administering a
combination of 100mg intramuscular (IM) ketamine and Crisis Response Plan (a short
psychosocial intervention) for patients with acute suicidality in the context of the
Emergency Department setting. This study will assess a combination of a pharmacologic
intervention and a psychosocial one. The pharmacologic intervention is a one-time dose of
100mg ketamine delivered intramuscularly (IM) while the patient is in the ED. The
psychosocial intervention under study is a brief, patient-centered therapy which takes, on
average, 30 minutes to administer. Both interventions will be administered only once. The
main questions this study aims to answer are:
- Determine if 100mg of IM ketamine and Crisis Response Plan in combination results in
greater short-term reductions in suicidal ideation in adult patients who report acutely
elevated suicide risk during an ED visit.
- Examine potential weight-based dose response differences in the reductions in suicidal
ideation to determine if future treatment protocols with IM ketamine may benefit from
weight-based dosing.
Phase:
Phase 2/Phase 3
Details
Lead Sponsor:
The University of Texas Health Science Center at San Antonio