Ketamine Versus Propofol Effect on the Immune-mediatory Response for Abdominal Surgery
Status:
Unknown status
Trial end date:
2019-08-15
Target enrollment:
Participant gender:
Summary
Host systemic responses to vigorous stimuli as trauma, surgical tissue injury, anesthesia and
post-operative pain, leads to release a variety of pro-inflammatory cytokines including
interleukin-1 (IL-1) and interleukin-6 (IL-6) mainly from monocytes and macrophages Thus, the
rise of IL-6 is regarded as an early marker of tissue damage and its rise proportional to the
degree of tissue damage .
It has been demonstrated that systemic responses to stress may be modified by the anesthetic
technique used . Total intravenous anesthesia (TIVA) especially propofol based greatly
suppresses the stress response induced by surgery when compared to inhalation by lowering
cortisol levels.
Ketamine has the ability to modulate (modify) inflammation . Even the sub-anesthetic doses of
ketamine in animal models were even provided to have an effect on the inflammatory response
system in the central nervous system