Overview

Ketamine / Propofol Admixture "Ketofol" at Induction in the Critically Ill Against Etomidate: KEEP PACE Trial

Status:
Completed
Trial end date:
2018-08-01
Target enrollment:
0
Participant gender:
All
Summary
The hypothesis of this study is that a Ketamine / Propofol mixture will produce more stable hemodynamics as compared to Etomidate during emergent intubations in the intensive care unit. Patients that require a breathing tube to be placed in the ICU will be randomized to receIve either a Ketamine / Propofol mixture or Etomidate for sedation in order to place the breathing tube.
Phase:
Phase 2/Phase 3
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Mayo Clinic
Treatments:
Etomidate
Ketamine
Propofol
Criteria
Inclusion Criteria:

- 18 years of age or older

- Surgical or medical intensive care unity patients requiring endotracheal intubation

- Consulting physician agrees to study plan and will follow drug randomization

Exclusion Criteria:

- Known intracranial pathology

- Known chronic opiate-dependence

- Received continuous sedative infusion in the last 24 hours

- Known severe psychiatric illness

- Known egg allergies

- Known contraindication to fentanyl, midazolam, ketamine, propofol or etomidate

- Intubation in which standard practice is not to use sedation

- No known documented weight or weight greater than 140 kg or less than 30 kg

- Prior participation in the study

- Of childbearing age (18-50) with no known negative pregnancy test on this admission.