Overview

Ketamine Infusion Therapy for the Management of Acute Pain in Adult Rib Fracture Patients

Status:
Completed
Trial end date:
2018-08-01
Target enrollment:
0
Participant gender:
All
Summary
This study will evaluate the effectiveness of ketamine infusions in the management of acute pain resulting from broken ribs suffered following a blunt trauma. Half of patients will receive the institutional standard of care and a placebo infusion (no active medication). The other half of patients will receive the institutional standard of care and a ketamine infusion. All subjects and staff will be blinded as to whether they are receiving placebo or ketamine.
Phase:
Phase 4
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Medical College of Wisconsin
Treatments:
Acetaminophen
Analgesics, Opioid
Ibuprofen
Ketamine
Methocarbamol
Narcotics
Pantoprazole
Criteria
Inclusion Criteria:

1. age greater than 18 years

2. rib fractures following recent trauma with admission to Froedtert Memorial Lutheran
Hospital

Exclusion Criteria:

1. history of adverse reaction / intolerance to ketamine therapy

2. elevated intracranial pressure

3. ischemic heart disease defined as active acute coronary syndrome

4. severe, poorly controlled hypertension (Systolic Blood Pressure > 200 mmHg or
Diastolic Blood Pressure > 100 mmHg)

5. current opiate agonist/antagonist therapy

6. concurrent use of monoamine oxidase inhibitors (MAOIs)

7. chronic pain or opioid tolerance defined as > 3 weeks of >30mg oral morphine
equivalents per day

8. current substance abuse with opiates (prescription and/or heroin) or ketamine

9. Glasgow Coma Scale <13

10. Intubation on arrival or need for urgent intubation on arrival

11. inability to delineate pain and/or appropriately communicate with staff

12. history of psychosis

13. three or more psychotropic medications

14. active delirium

15. glaucoma

16. pregnancy

17. prisoners