Overview

KPT-330 Plus RICE for Relapsed/Refractory Aggressive B-Cell Lymphoma

Status:
Active, not recruiting
Trial end date:
2021-12-01
Target enrollment:
Participant gender:
Summary
This study evaluates the addition of selinexor (KPT-330) to RICE chemotherapy in the treatment of relapsed and refractory aggressive B-Cell Lymphoma, with the goal of improved response rates (as compared to RICE chemotherapy alone).
Phase:
Phase 1
Details
Lead Sponsor:
Weill Medical College of Cornell University
Collaborators:
FDA Office of Orphan Products Development
Karyopharm Therapeutics Inc
Karyopharm Therapeutics, Inc
The Leukemia and Lymphoma Society
Treatments:
BB 1101
Carboplatin
Dexamethasone
Dexamethasone 21-phosphate
Dexamethasone acetate
Etoposide
Etoposide phosphate
Ifosfamide
Isophosphamide mustard
Rituximab