Joint Application of Human Insulin and Rapid Insulin Analogue in Control of Postprandial Glycemia
Status:
Unknown status
Trial end date:
2010-09-01
Target enrollment:
Participant gender:
Summary
Postprandial glycemic control is essential for diabetes compensation. Insulin pump therapy
control blood glucose released in response to both high and low glycemic index carbohydrates
in a mixed diet using normal, square and dual-wave boluses. The investigators hypothesize a
mixture of rapid insulin analogue and human insulin has the same effect.
This pilot prospective cohort study replaces basal-bolus therapy of diabetic subjects by
combined prandial application of insulin aspart and human insulin. Mixed-meals with high,
both high and low and low glycemic index carbohydrates are covered by 3:1, 1:1 and 1:3 ratios
of analogue to human insulin mixture. Subjects are followed by continuous glucose monitor for
six days (Phase One), changing between the experimental or their standard protocol for
insulin injection on consecutive days. The outcome was measured by comparing average glycemia
and areas under the curve of sample meals, which are doughnut, pizza and mixed vegetable
salad. The next three-to-four week period of therapy was evaluated by glycated hemoglobin
before and after the intervention (Phase Two).
Expected outcomes are postprandial and complex improvement of diabetes control, similarly to
the insulin pump therapy.