Overview

Ixazomib for Desensitization

Status:
Completed
Trial end date:
2021-04-16
Target enrollment:
0
Participant gender:
All
Summary
The purpose of this research study is to find out how well ixazomib (the study drug) works to desensitize highly sensitized kidney transplant recipients.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
University of Wisconsin, Madison
Collaborator:
Millennium Pharmaceuticals, Inc.
Treatments:
Glycine
Ixazomib
Criteria
Inclusion Criteria:

- Male or female patients 18-70 years of age.

- Able to provide informed consent.

- Female patients who are postmenopausal for at least 1 year before the screening visit,
or are surgically sterile, or If they are of childbearing potential, agree to practice
2 effective methods of contraception, at the same time, from the time of signing the
informed consent form through 30 days after the last dose of study drug, OR agree to
practice true abstinence when this is in line with the preferred and usual lifestyle
of the subject. (Periodic abstinence [eg, calendar, ovulation, symptothermal,
post-ovulation methods] and withdrawal are not acceptable methods of contraception.)

- Male patients, even if surgically sterilized (ie, status post-vasectomy), must agree
to one of the following: Agree to practice effective barrier contraception during the
entire study treatment period and through 30 days after the last dose of study drug,
or Agree to practice true abstinence when this is in line with the preferred and usual
lifestyle of the subject. (Periodic abstinence (eg, calendar, ovulation,
symptothermal, post-ovulation methods] and withdrawal are not acceptable methods of
contraception.)

- Patients must be highly sensitized with a cPRA ≥ 80%

- Be active on the waitlist for kidney transplantation > 24 months to confirm their
inability to receive a deceased donor transplant because of their sensitization
status.

- Patients must meet the following clinical laboratory criteria:

1. Absolute neutrophil count (ANC) ≥ 1,000/mm3 and platelet count ≥ 75,000/mm3.
Platelet transfusions to help patients meet eligibility criteria are not allowed
within 3 days before study enrollment.

2. Hemoglobin higher than 6 g/dL

3. Total bilirubin ≤ 1.5 x the upper limit of the normal range (ULN).

4. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 3 x ULN.

Exclusion Criteria:

- Female patients who are lactating or have a positive serum pregnancy test during the
screening period

- Major surgery requiring hospitalization within 6 months before enrollment

- Infection requiring systemic antibiotic therapy or other serious infection within 14
days before study enrollment

- Evidence of current uncontrolled cardiovascular conditions, including uncontrolled
hypertension, uncontrolled cardiac arrhythmias, symptomatic congestive heart failure,
unstable angina, or myocardial infarction within the past 6 months

- Systemic treatment, within 14 days before the first dose of ixazomib, with strong
CYP3A inducers (rifampin, rifapentine, rifabutin, carbamazepine, phenytoin,
phenobarbital), or use of St. John's wort

- Any serious medical or psychiatric illness that could, in the investigator's opinion,
potentially interfere with the completion of treatment according to this protocol

- Inability to take oral medication

- Diagnosed or treated for another malignancy within 2 years before study enrollment or
previously diagnosed with another malignancy and have any evidence of residual
disease. Patients with nonmelanoma skin cancer or carcinoma in situ of any type are
not excluded if they have undergone complete resection

- Grade 2 or greater peripheral neuropathy according to NCI Common Terminology Criteria
for Adverse Events (CTCAE)

- Participation in other interventional clinical trials, including those with other
investigational agents not included in this trial, within 6 months of the start of
this trial and throughout the duration of this trial

- Patients that have previously been treated with ixazomib, or participated in a study
with ixazomib whether treated with ixazomib or not

- Active or treated infection for HIV, HCV or HBV

- History of Liver cirrhosis, biopsy confirmed

- Elevated transaminases (greater than 3 times the upper limit of normal)

- Known hypersensitivity to ixazomib

- Active substance abuse by self-report or medical record