Overview

Itraconazole for Fungal Sensitive Chronic Rhinosinusitis With Nasal Polyps

Status:
Terminated
Trial end date:
2019-05-15
Target enrollment:
0
Participant gender:
All
Summary
The purpose of this randomized controlled double-blinded trial is to determine if the addition of an oral antifungal to typical post-operative medical therapy can prevent or reduce the incidence of recurrence of nasal polyps in fungal sensitive patients with chronic rhinosinusitis with nasal polyps (CRSwNP).
Phase:
Phase 2/Phase 3
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
The University of Texas Health Science Center, Houston
Treatments:
Hydroxyitraconazole
Itraconazole
Criteria
Inclusion Criteria:

- Meet criteria for diagnosis of CRS with nasal polyps undergoing medically indicated
sinus surgery

Exclusion Criteria:

- cystic fibrosis

- aspirin exacerbated respiratory disease

- uncontrolled or unstable chronic diseases such as uncontrolled diabetes

- active or history of cancer

- HIV positive

- history of liver or kidney disease

- history of disease with effects on immune system

- pregnant

- allergy to triazole antifungals