Overview

Isotretinoin Plus Dexamethasone in Treating Patients With Multiple Myeloma

Status:
Completed
Trial end date:
2005-10-01
Target enrollment:
0
Participant gender:
All
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining chemotherapy with dexamethasone may be an effective treatment for multiple myeloma. PURPOSE: Phase II trial to study the effectiveness of combining isotretinoin and dexamethasone in treating patients who have multiple myeloma.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Fox Chase Cancer Center
Collaborator:
National Cancer Institute (NCI)
Treatments:
BB 1101
Dexamethasone
Dexamethasone 21-phosphate
Dexamethasone acetate
Isotretinoin
Criteria
DISEASE CHARACTERISTICS: Histologically confirmed multiple myeloma Elevated monoclonal
protein in serum and/or urine

PATIENT CHARACTERISTICS: Age: 18 and over Performance status: ECOG 0-2 Life expectancy: Not
specified Hematopoietic: WBC at least 3,000/mm3* Platelet count at least 75,000/mm3*
*Unless secondary to multiple myeloma involvement of the bone marrow Hepatic: Bilirubin
less than 1.5 mg/dL Transaminase less than 2 times normal Renal: Creatinine less than 2.0
mg/dL No overt renal insufficiency Cardiovascular: No congestive heart failure No
myocardial infarction within the past 6 months No significant arrhythmia or poorly
controlled hypertension Pulmonary: No severe pulmonary disease Other: Triglycerides normal
No other severe medical illness No active peptic ulcer disease No brittle insulin-dependent
diabetes No severe depression or other psychiatric illness No active infection No history
of severe ethanol or drug abuse Not pregnant or nursing Negative pregnancy test Fertile
patients must use effective contraception

PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: No prior
chemotherapy Endocrine therapy: Not specified Radiotherapy: Prior palliative radiotherapy
allowed Surgery: At least 3 weeks since prior major surgery