Isotretinoin, Interferon Alpha-2b, and Paclitaxel in Stage IV, Recurrent, or Persistent Cervical Cancer
Status:
Terminated
Trial end date:
2010-11-01
Target enrollment:
Participant gender:
Summary
RATIONALE: Drugs used in chemotherapy, such as paclitaxel, work in different ways to stop the
growth of tumor cells, either by killing the cells or by stopping them from dividing.
Sometimes when chemotherapy is given, it does not stop the growth of tumor cells. The tumor
is said to be resistant to chemotherapy. Giving isotretinoin and interferon alpha-2b together
with paclitaxel may reduce drug resistance and allow the tumor cells to be killed.
PURPOSE: This phase II trial is studying how well giving isotretinoin and interferon alpha-2b
together with paclitaxel works in treating patients with stage IV, recurrent, or persistent
cervical cancer.
Phase:
Phase 2
Details
Lead Sponsor:
University of Medicine and Dentistry of New Jersey