Isotretinoin, Interferon Alfa, and Vitamin E in Treating Patients With Stage III or Stage IV Head and Neck Cancer
Status:
Completed
Trial end date:
2009-05-01
Target enrollment:
Participant gender:
Summary
RATIONALE: Drugs used in chemotherapy such as isotretinoin use different ways to stop tumor
cells from dividing so they stop growing or die. Interferon alfa may interfere with the
growth of tumor cells. Vitamin E may be able to decrease side effects caused by isotretinoin.
It is not yet known whether combining isotretinoin and interferon alfa with vitamin E is more
effective than observation in preventing recurrence of head and neck cancer after surgery
and/or radiation therapy.
PURPOSE: Randomized phase III trial to compare the effectiveness of isotretinoin and
interferon alfa combined with vitamin E with that of observation in treating patients who
have undergone surgery and/or radiation therapy for stage III or stage IV head and neck
cancer.
Phase:
Phase 3
Details
Lead Sponsor:
Eastern Cooperative Oncology Group
Collaborator:
National Cancer Institute (NCI)
Treatments:
alpha-Tocopherol Interferon-alpha Interferons Isotretinoin Tocopherols Tocotrienols Vitamin E Vitamins