Isonicotinic Acid Hydrazide (INH) Pretreatment With Misoprostol Versus Misoprostol Alone in Missed Abortion

• Status: Not yet recruiting
• Trial end date: 2021-07-30
• Target enrollment: 0
• Participant gender: Female

Summary

The primary endpoint was the success rate of adjuvant isonicotinic acid hydrazide (INH) and misoprostol versus misoprostol alone for medical termination of first-trimester pregnancy.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Aswan University Hospital
• Treatments: Isoniazid; Misoprostol

Criteria

Inclusion Criteria:

• Gestational age less than 70 days gestation (<10 wks)

• Hemoglobin >10 g/dL.

• BMI between 18.5 kg/m2 and 30 kg/m2.

• Missed abortion

Exclusion Criteria:

• Molar pregnancy.

• Fibroid uterus.

• Uterine anomalies.

• Coagulopathy.

• Medical disorder that contraindicate induction of abortion (e.g. heart failure).

• Previous attempts for induction of abortion in the current pregnancy.

• Allergy to misoprostol or letrozole.

• Scared uterus (previous myomectomy, cesarean section, hysterectomy and ruptured uterus).