Isoflavones and the Coronary Circulation in Men and Women With Coronary Artery Disease

• Status: Completed
• Trial end date: 2003-08-18
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study is to investigate the effect of genistein administration on coronary arteries in humans. We will measure the size of a coronary artery and the speed and amount of blood flow in response after subjects have ingested Supro® drinks (a soy protein drink containing genistein).

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Imperial College London
• Treatments: Genistein

Criteria

Inclusion Criteria:

• Aged 30-75 years

• Patients requiring diagnostic coronary angiography

• Presence of coronary artery disease on angiogram but with at least one non-obstructed (lesions <70% narrowed compared with the adjacent normal part of the vessel) atheromatous vessel (confirmed at diagnostic cardiac catheterisation)

• Female patients must be postmenopausal (FSH>40 IU/L)

• Willing to give informed, written consent

Exclusion Criteria:

• Age <30 or >75 years

• Allergy to radiographic contrast media

• Sino-atrial disease or significant bradycardia

• Concomitant medication with persantin (dipyridamole) or theophyllines

• Asthma

• Hypertension

• Left ventricular hypertrophy or dysfunction (clinical/ECG/echo/CXR)

• Female patients with FSH<40 IU/L (postmenopausal)

• Female patients currently taking hormone therapy, or who have taken hormone therapy in previous 6 months

• Unwilling to give written informed consent

• Participation in another study within previous 60 days