Islet Cell Transplantation Alone and CD34+ Donor Bone Marrow Cell Infusion in Type 1 Diabetes Mellitus
Status:
Completed
Trial end date:
0000-00-00
Target enrollment:
Participant gender:
Summary
SPECIFIC AIMS:
- To reverse hyperglycemia and insulin dependency in patients with Type 1 diabetes
mellitus by islet cell transplantation.
- To induce a state of donor specific tolerance and eliminate the need for continuous
immunosuppressive therapy by simultaneous transplantation of donor bone marrow cells
with islets and utilization of the monoclonal antibody Campath-1H for induction of
Immunosuppression.
- To assess long-term function of successful islet cell transplants in patients with Type
1 diabetes mellitus.
- To determine whether the natural history of the microvascular, macrovascular and
neuropathic complications are altered following successful transplantation of islet
Phase:
Phase 2
Details
Lead Sponsor:
University of Miami
Collaborator:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)