Ischemic Injury and Ischemic Preconditioning in Diabetes
Status:
Completed
Trial end date:
2005-05-01
Target enrollment:
Participant gender:
Summary
In this proof-of-concept study, forearm vulnerability to ischemic exercise is studied in
patients with type 1 diabetes mellitus with and without prior ischemic preconditioning (short
period of ischemia that protects against subsequent ischemic exercise). Annexin A5
scintigraphy is used to quantify subtle signs of mild and reversible forearm injury that
results from ischemic exercise.
The following hypotheses are tested:
1. Patients with type 1 diabetes are not more vulnerable to ischemic injury as compared
with previously studied healthy volunteers.
2. Ischemic preconidtioning is still present in patients with type 1 diabetes. Depending on
the validity of hypothesis 2, the effect of short pharmacological interventions are
studied on vulnerability to forearm ischemia/reperfusion injury in the absence or
presence of local forearm ischemic preconditioning.