Ischemia/Reperfusion Injury of Human Endothelium: Role of Glucose and Statins
Status:
Completed
Trial end date:
2013-09-01
Target enrollment:
Participant gender:
Summary
Anesthetic preconditioning (APC, a brief exposure to an anesthetic gas) has become an area of
intense research interest because of its ability to protect tissue and organs from injury
resulting from a cessation of blood flow and then a re-establishment of flow. The blood
vessel lining plays a key role in this injury. This research will examine, in human
volunteers, several important modifiers of APC in human blood vessels: high blood sugar,
vitamin C, and statin drugs. Thus, the proposed studies will advance the investigators'
understanding of mechanisms of this injury in humans and explore important modifiers of APC
protection from injury.
Phase:
N/A
Details
Lead Sponsor:
US Department of Veterans Affairs VA Office of Research and Development