Overview

Ischaemia-réperfusion During the Coronary Surgery With Beating Heart

Status:
Unknown status
Trial end date:
1969-12-31
Target enrollment:
0
Participant gender:
All
Summary
Less oxidative stress occurs during off-pump than on-pump coronary artery bypass graft (CABG) surgery but warm ischaemia-reperfusion injury may occur following transient coronary artery clamping. The aim of this study was to compare the preventive effects of diltiazem and N-acetylcysteine (NAC), alone or in combination, on biomarkers of myocardial damage and oxidative stress during off-pump CABG surgery.
Phase:
Phase 3
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
University Hospital, Strasbourg, France
Treatments:
Diltiazem
Pharmaceutical Solutions
Criteria
Inclusion Criteria:

- Age included between 60 and 80 years

Exclusion Criteria:

- Age < 60 or > 80 years

- Pregnancy

- The allergy in used medicines (N-acétylcystéine, Diltiazem)

- Presence of a pathology valvulaire associated

- Urgency

- Unstable angor

- Bypass as a matter of urgency

- Recours peropératoire to a CEC

- FE < 0,40

- BAV of the 2nd and 3rd not sailed degree

- fibrillation or flutter little finger.