Is Vitamin D2 Treatment-associated Decrease in 25(OH)D3 Level a Reciprocal Phenomena?

• Status: Completed
• Trial end date: 2017-11-20
• Target enrollment: 0
• Participant gender: All

Summary

Several studies have demonstrated that D2 treatment is associated with a decrease in 25(OH)D3 level and therefore have proposed that D3 would be preferable in term of raising total 25(OH)D level. The investigators postulate that the D2 treatment-associated decrease in 25(OH)D3 level may be related to an increase in total 25(OH)D level rather than being specific to D2 treatment, and thus there would be a D3 treatment-associated decrease in 25(OH)D2 level.

The investigators plan to conduct a double-blind placebo-controlled trial to examine the effect of D3 treatment on 25(OH)D2 level and the effect of D2 treatment on 25(OH)D3 leve

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: King Faisal Specialist Hospital & Research Center
• Treatments: Calcifediol; Cholecalciferol; Ergocalciferols; Vitamin D; Vitamins

Criteria

Inclusion criteria:

• non-pregnant adults (age ≥18 years)

• healthy

• total 25(OH)D level between 20 to 65 nmol/L.

• living in Riyadh area

Exclusion criteria:

• consumption of more than one serving of milk daily

• taking vitamin D supplements

• habitual weekly sun exposure of 10 hours or more

• history of granulomatous, liver, or kidney disease

• taking anticonvulsants, barbiturates, or steroids