Is Spontaneous Bacterial Peritonitis Still Responding to 3rd Generation Cephalosporins?
Status:
Unknown status
Trial end date:
2019-12-01
Target enrollment:
Participant gender:
Summary
Current European and most other international guidelines recommend the use of a
third-generation cephalosporin as the first choice, or amoxicillin-clavulanate acid or
fluoroquinolones as an alternative choice .
These recommendations are based mainly on clinical trials that were very often conducted a
decade or more ago, and on the assumption that E. coli would be involved in nearly half of
the cases.
The microbial etiology of SBP remains relatively constant; however, the antibiotic resistance
rate especially for third-generation cephalosporins (including cefotaxime and ceftazidime),
ciprofloxacin, and ofloxacin increased dramatically .