Is Pentoxifylline Able to Improve Olfactory Sensitivity?

• Status: Completed
• Trial end date: 2016-01-01
• Target enrollment: 0
• Participant gender: All

Summary

Signal processing in the olfactory neuron could be influenced by inhibition of enzymes like phosphodiesterase. Pentoxifylline is a unspecific phosphodiesterase inhibitor. The hypothesis is that pentoxifylline could lead to increased sensitivity to odors.

• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Technische Universität Dresden
• Treatments: Pentoxifylline

Criteria

Inclusion Criteria:

• hyposmic or functionally anosmic patients TDI-score <31

• age: 18-50 years

• odor threshold: better than 1

• cause of smell loss: post traumatic, postinflammatory, idiopathic

Exclusion Criteria:

• normosmic patients,

• patients with contraindications for application of pentoxifylline

• patients that cannot give written agreement to the study

• patients under 18 years and over 50 years of age