Is Insulin Resistance and/or Glucose Intolerance Pathogenetic in the Development of a Reduced Incretin Effect

• Status: Completed
• Trial end date: 2009-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to examine whether there is a causal relationship between insulin resistance and/or glucose intolerance in the development of a defect incretin effect.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University Hospital, Gentofte, Copenhagen
• Treatments: BB 1101; Dexamethasone; Dexamethasone 21-phosphate; Dexamethasone acetate; Incretins

Criteria

Inclusion Criteria:

• Caucasians >20 years

• Normal glucose tolerance as assessed by the WHO criteria

• First degree relative and at least 1 second degree relative with type 2 diabetes

• Normal haemoglobin

• Informed consent

Exclusion Criteria:

• Liver disease (ALAT/ASAT > 2 times normal value)

• Kidney disease (S-creatinin > 130uM and/or albuminuria)

• Heart disease (NYHA II, III or IV)

• Treatment with medicine that cannot be paused

• Pregnancy of breast feeding