Is Blood Flow Through IPAVA and PFO Related to Breath-hold and SCUBA Diving-induced Pulmonary Hypertension?

• Status: Enrolling by invitation
• Trial end date: 2021-12-01
• Target enrollment: 0
• Participant gender: All

Summary

In summary, the investigators propose to study elite Croatian breath-hold and SCUBA divers. The investigators will quantify breath-hold hypoxia- and SCUBA diving-induced pulmonary hypertension and right heart function to investigate the relationships between PFO and IPAVA blood flow. The investigators will use a placebo-controlled intervention (sildenafil) to reduce pulmonary arterial pressure in these subjects to examine the impact of the change in pressure (or absence of change) on the relationships determined above.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Oregon
• Treatments: Sildenafil Citrate

Criteria

Inclusion Criteria:

• Reside in geographic location near Split, Croatia

• Elite breath hold divers

• Experienced SCUBA divers

Exclusion Criteria:

• Previous history of coronary artery disease

• Currently taking medication or herbal supplement for any heart or respiratory disease that cannot be ceased for 48 hours prior to testing

• Women who are pregnant or trying to become pregnant

• Previous history of any condition that would prevent the subject from performing a breath hold

• Taking sildenafil or products similar to sildenafil

• Taking Nitrates or other nitric oxide donors

• Control breath hold divers can't have previous breath hold diving experience